Preclinical models of disease to foster clinical translation
Date/Time: Monday, July 22, 2019 - 1:30 PM to 3:30 PM
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The use of adequate preclinical models that clearly reflects patient situation when developing drug delivery technologies is a key issue to accelerate translation from lab to clinic. The preclinical data sets need to comprehensively evaluate therapeutic efficacy, safety, biodistribution, and pharmacokinetics in appropriate complex cell or animal models of the disease that are relevant to human disease. An example of such models will be presented by Prof Satchi-Fainaro including human-derived. Also, reliable 3D models for a fast screening is also a need to enhance drug attrition rate minimizing costs for translation, Ocello is a clear example of the application of such needs with the patient-derived organoid technology.