Plenary Session 2
New Approaches in Imaging and Sensing of Drug Action
Date/Time: Monday, July 22, 2019 - 8:00 AM to 9:00 AM
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We have been interested in understanding how drugs work (on specific pathways, on different cell types and in different tissues/organs/diseases), what the variability in patient response is and why many cancer treatments fail (“systems pharmacology”). Using a broad array of technologies including in vivo imaging, novel sensing approaches and chemical biology we obtain quantitative measurements and then develop mechanistic and probabilistic models. Ultimately, we hope to improve our poor understanding of treatment response and define new targets drugs to tackle complex diseases. In this presentation, I will focus on three particular aspects of our research:
- Review the state-of-the art of single cell imaging of drug distribution and action (“PK/PD imaging”);
- Focus on the growing realization that myeloid derived cells often play an important role as therapy modulators; and
- Review new sensor technologies for longitudinal treatment monitoring and molecular diagnostics in patients.