Importance of a Rational Design: Carrier, Linker, Cargos
Date/Time: Tuesday, July 23, 2019 - 10:00 AM to 12:00 PM
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Drug delivery systems can improve the pharmacokinetic and biodistribution characteristics of drugs, thus reducing side-effects and improving therapeutic efficacy. Liposomes, micelles, polymersomes, or polymer–drug conjugates, among other nano-platforms, have been approved or entered clinical trials. Notably, the physicochemical properties of carriers, including surface properties (charge, hydrophilicity), size, and shape are vital for drug delivery. Linkers between drugs and polymers/carriers are key for the stimuli triggered drug release of prodrugs. The amount and properties of cargos determine the sensitivity to the treatment. This session addresses the rational design of carriers, linkers, and cargos, which are vital for in vivo performance.