Detailed Characterization of Liposomes and Other Nanoparticle-based Therapeutic Delivery Formulations With Field-flow Fractionation and Light Scattering (FFF-MALS)

Pre-Meeting Workshop

Date/Time: Saturday, July 20, 2019 - 8:00 AM to 12:00 PM
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One of the primary challenges in developing and commercializing novel nanoparticle-based therapies is detailed characterization of the formulation components. FFF-MALS technology, which couples light scattering and other online detectors to field-flow fractionation, addresses this challenge. The workshop will explore applications of FFF-MALS to characterization of nanoparticle drug and gene delivery formulations to determine high-resolution size distributions, drug loading and release, and particle structure. The relevance of FFF-MALS to meeting FDA requirements for liposome formulations will be discussed. Scientists involved in the analysis and characterization of nanoparticle or lipid-based drug formulations should attend.


Introduction to the Theory of Field-Flow Fractionation and Multi-Angle Light Scattering
Dr. Christoph Johann, Wyatt Technology, U.S.A.

9:30am – 10:30am
Asymmetrical Flow Field-Flow Fractionation for the Characterization of Colloidal Lipid Based Formulations
Judith Kuntsche, University of Southern Denmark, Denmark

10:45am – 11:15am
Characterization of Lipid Based and Non-Lipid Based Gene Delivery Formulations
Daniel Some, Wyatt Technology, U.S.A.

11:15am – 11:30am
Relevance of FFF-MALS for the Requirements of the FDA Guideline for Liposome Drug Products
Dr. Christoph Johann, Wyatt Technology, U.S.A.

11:30am – 12:00pm
Open Discussion Session, Q+A between attendees and speakers